"A Million Little Fibers" is the fifth episode in the tenth season of the American animated television series South Park. The 144th episode of the series overall, it was first broadcast on Comedy Central in the United States on April 19, 2006. It is one of two episodes where main characters Stan, Kyle, Kenny, and Cartman do not make an appearance, the other being Pip. The episode focuses on Towelie and parodies the controversy over the book A Million Little Pieces, an infamous novelistic memoir by James Frey that was lauded by Oprah Winfrey on her talk show until it was revealed to be largely fabricated.

The episode was written and directed by series co-creator Trey Parker. It was intended as season ten's "bank episode", meaning it was partially produced in advance to allow for time off during the actual production run. However, the episode practically had to be scrapped, as it required more time than was allowed to be finished. The original plot of the episode parodied the television series Intervention. The episode received a mixed to negative critical reception.